| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e3830f35387a1c32061dea3ee310851
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8366fe8e8b9d6da9135e1ceaa77382b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2058b9560c8c622c687cedd382b77671
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_379718cfd53cbb9d9caed983565e3310 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2010-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3668b07eaf12a0e595fdb6e7574d045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa6e95cbc64c0ebcf0a86a9dbe170d8f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f50b2c36875a89ba6d0a8a342d90123 |
| publicationDate |
2011-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011020012-A1 |
| titleOfInvention |
Lack of expression of tnfa and type 1 receptor for tnfa protects cancer cells from tnfa-induced programmed cell death (cell apoptosis) |
| abstract |
The present invention includes compositions and methods for determining whether a subject is a candidate for TNFα treatment. The invention includes assessing the methylation status of the TNFα promoter and expression of type 1 TNFα receptor (TNF-Rl) in a cell from the subject. Hypermethylation of the TNFα promoter and/or expression of TNF-Rl is an indication that the subject is suffering from cancer and is capable of responding to TNFα treatment accomplished by induction of expression of endogeneous TNFα and/or administration of exogeneous TNFα. |
| priorityDate |
2009-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |