| abstract |
Disclosed is a novel azabicyclo compound which has both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by general formula (I) or a salt thereof. (In the formula, X 1 represents CH or N; one of X 2 , X 3 and X 4 represents N, and the others respectively represent CH; one or two of Y 1 , Y 2 , Y 3 and Y 4 respectively represent C-R 4 , and the others may be the same or different and respectively represent CH or N; R 1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group that has 1-4 heteroatoms selected from among N, S and O; R 2 represents an alkyl group having 1-6 carbon atoms, or the like; and R 3 and R 4 respectively represent -CO-R 5 or the like.) |