| abstract |
Methods to treat and provide pain relief for damaged and degenerated tissues of a musculoskeletal joint are disclosed. These methods include introducing into, around and/or on the musculoskeletal joint an effective amount of a pharmaceutical composition containing a biocompatible matrix or biocompatible polymeric compound, a pain reliever, and a corticosteroid formulated for extended-release, wherein at least a portion of the biocompatible matrix or biocompatible polymeric compound is activated and polymerized in situ . Also disclosed is a composition for treating a damaged or degenerated joint or soft tissue. The composition contains a polymerizable material capable of forming a biocompatible and biodegradable matrix in situ at a treatment site, a pain reliever; and a corticosteroid formulated for extended-release. |