| abstract |
Disclosed is a medicine which contains, as an active ingredient, a highly safe compound that exhibits extremely strong chymase inhibitory activity for prevention and/or treatment of chymase-mediated diseases, such as skin diseases, cardiovascular diseases, digestive diseases, respiratory diseases, hepatic diseases or eye diseases, while having high metabolic stability.nSpecifically, a compound represented by general formula (I) (wherein all the symbols are as defined in the description), a salt thereof, an N-oxide form thereof, a solvate of any of those or a prodrug of any of those is useful as a medicinal ingredient having chymase inhibitory activity for prevention and/or treatment of chymase-mediated diseases, such as skin diseases, cardiovascular diseases, digestive diseases, respiratory diseases, hepatic diseases or eye diseases. |