http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010142295-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_98b7cc484913a20e59d0734ea54f71d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43fe117d5e377852bbddf9b05a6702ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_438d40f301ad1e0d0bf5c2113bcf1fe1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49685d3b6e6d2e35e8275935f6440f95 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4716 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-564 |
| filingDate | 2010-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_881f87e591dc4baa77cac3a12c0d1d97 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b85205cf08a250cd9512eceebe40f4b |
| publicationDate | 2010-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2010142295-A1 |
| titleOfInvention | Ficolin-3 assay |
| abstract | The present invention relates to methods for detecting Ficolin-3 dependent activation of the lectin pathway of complement, methods for identifying abnormalities in Ficolin-3, and methods for screening for deficiencies/and or identifying abnormalities in any downstream components of the Ficolin-3 dependent activation of the lectin pathway of 5 complement using an acetylated Ficolin-3 ligand, said methods generally comprising the steps of: (a) providing a sample of blood, serum, plasma, another body fluid or an extract thereof; (b) (optionally) preventing in the sample activation of the classical pathway and/or the alternative pathway and/or any non-Ficolin-3 mediated activation of the lectin pathway; (c) acetylating a molecule; (d) contacting said acetylated molecule 10 with said sample, in conditions that permit specific binding of Ficolin-3 to said acetylated molecule, and, (e) detecting and quantifying specific binding of the Ficolin-3 to said acetylated molecule, (f) determining in the sample complement activation and/or deposition by the detection of a C2, C3, C4 and/or a C5 cleavage product and/or by detecting any of the terminal complement complex components C6, C7, C8 or C9 or 15 the C5b-9 terminal complement complex as such. The present invention also provides assays and kits comprising the methods of the invention. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9518250-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2748309-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013000471-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014520765-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9012154-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104114694-A |
| priorityDate | 2009-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.