| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01733884cc888894a4579e6d14f90508
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_58bfacd30a17c24c3966b3e64df48d3f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c66f68e0bf9501e55a226e4f50521f14 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-21 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-501 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 |
| filingDate |
2010-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc9c05652922ea017bba1013ad065142
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a74ae93281ea401f9a00402f82b8ecd3 |
| publicationDate |
2010-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010135491-A2 |
| titleOfInvention |
Fibroblast growth factor mutants having improved functional half-life and methods of their use |
| abstract |
Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016172153-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9925243-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11542309-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014045751-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10398759-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10159711-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2930181-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11479590-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3285793-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10336799-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9925241-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10293027-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9783587-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9808508-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10695404-B2 |
| priorityDate |
2009-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |