http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010135004-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ffa391e3452713c04335830e77ee6da0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-32 |
| filingDate | 2010-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3d69553e2ea4dd17679188c0e1eb812 |
| publicationDate | 2010-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2010135004-A1 |
| titleOfInvention | Enzymatic degradation of a2e and other bisretinoid compounds of rpe lipofuscin |
| abstract | The present invention provides methods for reducing the amount of lipofuscin compounds present in a cell which comprises contacting the cell with an amount of an enzyme sufficient to directly or indirectly degrade the amount of lipofuscin compounds, so as to reduce the amount of lipofuscin compounds, wherein the enzyme is a carotenoid cleaving dioxygenase or an oxo-iron heme-based enzyme. The invention also provides methods for. treating a subject suffering from a lipofuscin- associated disorder which comprises administering to the subject a composition comprising an amount of an enzyme sufficient to directly or indirectly degrade lipofuscin compounds associated with the disorder in cells of the subject, so as to thereby treat subject's the lipofuscin- associated disorder, wherein the enzyme is a carotenoid cleaving dioxygenase or an oxo-iron heme-based enzyme. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021069217-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3006028-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9943525-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3784795-A4 |
| priorityDate | 2009-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.