| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0736f2ef291cec7526de02eaf5d9e5e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8586cabf3c624aa25208db73c07657f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf2a3a767ae32dfcda1f4e6642aeadc9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d2f623a5b8eacccb8a2f22c40dc4f803 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2010-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_608486836e8c8c4a269202fddf32efd2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6690d16fbbe3464d8aa89e9e14f772ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85ce6dca99967f37d8675c537dba7557 |
| publicationDate |
2010-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010133298-A1 |
| titleOfInvention |
Control of uric acid homeostasis |
| abstract |
The invention relates to vectors and mammalian cells in a system useful for switching on or switching off gene expression in response to uric acid. In a particular embodiment the invention relates to a mammalian cell useful in detecting and/or degrading a harmful excess of uric acid comprising (a) a vector comprising a genetic code for the uricase sensor-regulator HucR from Deinococcus radiodurans R1 fused to a transactivation domain or a transrepressor domain; and (b) a vector comprising the corresponding operator sequence hucO from Deinococcus radiodurans R1 specifically binding the bacterial uric acid sensor-regulator HucR, a promoter and a polynucleotide coding for an endogenous or exogenous protein, e.g. a protein interacting with uric acid. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104278031-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10557119-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10869898-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11576934-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11554141-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021083278-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019183292-A1 |
| priorityDate |
2009-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |