| abstract |
Disclosed is a polymer conjugate of a bioactive substance, which enables drug release independent of a biological enzyme and can be expected to have a high therapeutic effect. Specifically disclosed is a polymer conjugate of a bioactive substance, in which a substituent represented by general formula (I) or (II) is linked, through an amide bond, to at least one of the side-chain carboxy groups of a block copolymer comprising a polyethylene glycol structural moiety and a polymer having two or more carboxy groups. In formulae (I) and (II), R 8 and R 9 each independently represent a hydrogen atom or a C1-C6 alkyl group which may have a substituent; R 10 represents a hydrogen atom, a C1-C40 alkyl group which may have a substituent, a C1-C40 aralkyl group which may have a substituent, an aromatic group which may have a substituent, an amino acid residue having a protected carboxy group, or a sugar residue which may have a substituent; CX-CY represents CH-CH or C=C (double bond); A represents a residue obtained by removing, from a bioactive substance having one or more hydroxy groups, one of the one or more hydroxy groups. |