| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40f7edeafb08c56d8b11c1520baeb802
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a72e325062c68e7917a1962a924bc1a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a10dc651e733b8d5a1ec5684b812362 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-6068
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55516
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55555 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1277
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-739
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate |
2010-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0bd09b5adf628bb44aa89cb3cabc2cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3c8f8239742f1e786452538d30aeaf0 |
| publicationDate |
2010-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010130896-A2 |
| titleOfInvention |
Method for admixing the lipopolysaccharide (lps) of gram-negative bacteria |
| abstract |
The invention relates to a method for admixing the LPS of a gram-negative bacteria, according to which: (i) LPS or LPS liposomes (LPS formulated in liposomes) is/are mixed with the lipidated sub-unit B of the receptor of human transferrine (lipidated TbpB) of Neisseria meningitidis or a lipid fragment thereof; or (ii) LPS and the lipidated TbpB of N. meningitidis or a lipid fragment thereof are formulated together in liposomes; or (iii) LPS is conjugated with the TbpB of N. meningitidis or a lipid fragment thereof; in order to obtain a preparation that does not contain any OMVs and can induce, following administration to a mammal, an improved anti-LPS immune response compared to the anti-LPS immune response observed following administration of the corresponding preparation in which the lipidated TbpB of N. meningitidis or a lipid fragment thereof is omitted. The invention also relates to the vaccine compositions obtained by said method. The LPS can be, for example, the LOS of nonenteric gram-negative bacteria such as N. meningitidis. |
| priorityDate |
2009-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |