http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010130814-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75ec0c27b1ba0497fb8a419f0783cdaa http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8f3fc0bcee25a1161415431ccb1faf7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-108 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-06 |
| filingDate | 2010-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ee0b3450c8c450e93aee82257770b6d |
| publicationDate | 2010-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2010130814-A1 |
| titleOfInvention | Method for preparing a pharmaceutical formulation of lanthanide chelate in powder form |
| abstract | The present invention relates to a method for preparing a pharmaceutical composition of lanthanide chelate in powder form, said powder including an excess of free chelate of 0.002% to 0.4% mol/mol, said method including the following consecutive steps: 1) step 1: mixing the chelate and the lanthanide in order to carry out the complexing of the lanthanide by the chelate, the resulting complexing solution including, in addition to the lanthanide-chelate complex, an amount X1 of excess free chelate; 2) step 2: preferably measuring X1 and optionally adjusting X1 to obtain a value of X1 of 0.002 to 0.4% mol/mol; 3) step 3: precipitating the complexing solution obtained in step 1) or in step 2) in an organic solvent in order to produce a lanthanide-chelate complex powder, the powder containing an amount X2 of excess free chelate, 4) step 4: optionally adjusting X2 such that: 4.a) X2 is 0.002% to 0.4%, specifically 0.02% to 0.3% mol/mol, very advantageously 0.025% to 0.25% mol/mol; 4.b) X2 is 0.2 to 2 times X1, in particular 0.5 to 1.5 times X1, X2 advantageously belonging to the range: [0.5 - 0.95]*X1, or to the range [1.05 - 1.3]*X1.5); step 5: preferably measuring X2. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2786768-A1 |
| priorityDate | 2009-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.