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publicationDate 2010-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2010129965-A1
titleOfInvention Cancer specific mitotic network
abstract Developed here is a mitotic network comprising a signature of up to 54 genes, and including also sub-sets of genes within the signature, which can identify members by requiring higher correlation values for a signature gene. The present mitotic network provides for methods for prognosis and diagnosis of various cancers. The mitotic network is conserved across cancers exhibiting aberrant mitotic activity and several genes in the network act as therapeutic targets. Development of other inhibitors of mitosis can apply expression values of the genes in the mitotic network from patient tissue to select patients during clinical validation of the new drugs.
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