| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4a62e4f9698cbbaca65386c51735dd0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_948b610b39c4161a04e95e10edaa2255
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d6f7da1e425c8a3ef1da21e08f4c196
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4737d898afc5601a86d0a2b18d48239d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a9c513aaa1d4c7ad836dc1cb83568e8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-444
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-4445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-4435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-38 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3691
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3658
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-442
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3856
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-44 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-44 |
| filingDate |
2010-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2272172bc3c4d02682f3d27358f1a4a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bd3d5cfe02c1ce80ed5936614b6ea83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdc4d6ef41d0aec52e3599cb59a78e50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf94c79cbba280d8c5b97800dba7bcbd |
| publicationDate |
2010-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010129692-A1 |
| titleOfInvention |
Composite tissue-engineered intervertebral disc with self-assembled annular alignment |
| abstract |
The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell- mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111867645-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111867645-B |
| priorityDate |
2009-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |