| abstract |
The present invention relates to a method and means, in particular, drug delivery agent(s), a kit and compositions, for delivery of drugs to the chorio-retina and the optic nerve head. The method comprises contacting the surface of the eye with an effective amount of drug for treatment of chorio-retina and optic nerve head and a physiologically acceptable amount of at least one drug delivery agent, for enhancing delivery of the drug to these tissues in an ophtalmologically acceptable carrier, said drug delivery agent being selected from the group consisting of cholinergic agents, derivatives thereof or mixtures thereof. The present invention also relates to such drug delivery agent(s) or to compositions comprising such drug delivery agent(s) for use for the transfer, to the posterior segment of one or both eye(s), of at least one second drug that treats disorders and/or diseases of the eyes. The drug delivery agent(s) can be used in conjunction with at least another drug delivery agent which is an adrenergic agent selected from the group consisting of alpha adrenergic agonist agents, derivatives of the alpha adrenergic agonist agents, beta-blocking agents, derivatives of the beta-blocking agents and mixtures thereof. |