Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd656439ab15d45443c6dc65a2ca298f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2619f77a035b644f804e836fdff3ae4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_65237293ff8e66bc177c2627e01ea6fe |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y305-03001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-78 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-43 |
filingDate |
2010-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0b7d68961db4f6ef9dc11c3d3975d70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50e9791dd62506d22617659f49f5509a |
publicationDate |
2010-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2010124547-A1 |
titleOfInvention |
Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents |
abstract |
Mono-pegylated arginase conjugate and method producing thereof. The mono-pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral infections. The method of producing such arginase conjugate has a main step of genetically modifying the gene encoding an arginase so that the PEG moiety can attach to the enzyme at a predetermined, specific intended site. This is achieved by removing the PEG attaching amino acid residues at undesirable sites while keeping (or adding, if necessary) the one at the desirable site of the enzyme. Two exemplary mono-pegylated arginase conjugates so produced are human arginase I (HAI) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys 45 of the enzyme and Bacillus caldovelox arginase (BCA) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys 161 of the enzyme. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9109218-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20140107616-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20140108577-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102076348-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102076364-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013097657-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103184208-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103184208-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103184209-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103184209-B |
priorityDate |
2009-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |