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filingDate 2010-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2010-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2010124547-A1
titleOfInvention Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents
abstract Mono-pegylated arginase conjugate and method producing thereof. The mono-pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral infections. The method of producing such arginase conjugate has a main step of genetically modifying the gene encoding an arginase so that the PEG moiety can attach to the enzyme at a predetermined, specific intended site. This is achieved by removing the PEG attaching amino acid residues at undesirable sites while keeping (or adding, if necessary) the one at the desirable site of the enzyme. Two exemplary mono-pegylated arginase conjugates so produced are human arginase I (HAI) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys 45 of the enzyme and Bacillus caldovelox arginase (BCA) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys 161 of the enzyme.
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0A6E5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0CII7
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2LT97
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7GKP8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP17329
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1A1W7
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID854096
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7GTP0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP51009
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5LWG3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA0PW79
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8P8J4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA3MNB7
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3702521
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB8DH28
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID60545731
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7M7P6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0C0G7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7GGQ9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9KNT8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0C0G6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1IE03
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ3J9C8
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID33931
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5LXZ8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4T6Q0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP59412
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB1YD06
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID129129178
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID374193
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0JM14
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7NRJ9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2N9H9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5FQ73
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5YS62
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8G1A4
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID984368
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6TEJ0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7GTR5
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426146645
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7IV32
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7H6Y5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6ACL1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6HCP7
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID9735922
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5UZ46
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9SPU7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB8DN64
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0K4D8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO67213
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ64467
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1J5Q4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0I061
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5FWI5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP59602
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3923735
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID61390715
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC1KV84
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ94469
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO27322
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7J0T5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9TKU7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1IIZ2
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID45098721
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8PK26
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB4RQS8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8G7L2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2NEC4
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID12721
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7MH72
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO28032
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1AG76
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7GYN4
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID60603892
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP59606
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ94819
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0R9X5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5M2K2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA3CYG8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP59605
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP68770
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ3JWY8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ94818
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC5CAM5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP59604
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP21328
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ117P0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9K576
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6TL10
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP59603
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP17721
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5WED8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ03W70
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID41326032
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8CQG5
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID58015846
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP59609
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1IWM3
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID45123573
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB6YUU0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ87XM3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0C0B4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB8E0N9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC6A312
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP9WN83
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP59608
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7HRS7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ11D10
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0I4M1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0C0B3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP9WN82
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP59607
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA3N4T7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2G6Y6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5XAY2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP21329
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB4S7R9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO52631
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID885645
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID4336216
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1ATU4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP59846
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ929S9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1JAR2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0I607
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9UX31
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5M8Z6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5GDA4
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID4344564
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0KBW5
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID41355345
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB1H0L3
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3996871
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ3K3Q4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB4S9U5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC5CUG9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5EXR1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5N1Z2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8GL82
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3921745
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA3NQI1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1AVI7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ98E81
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC0MD79
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ3K7K0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6L1N7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6U068
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7H4E9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC0MBK4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP71276
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB9DIU4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0IFL5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2GKD7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0KUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6AR59
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5JHB5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP70685
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC1CXR6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5E7U3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9BDR3
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID100009074
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC5D679
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA0QBT9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7MYD8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1AZB7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1WV65
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ95SX7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2YZ66
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID40812
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9BM60
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB8EBG0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5GPT0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP61521
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP61520
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ57FU2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA0QWW2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8Q0U5
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID4782292
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID33824
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7IK29
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP61525
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID9750
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID380488
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1JFY9

Total number of triples: 1131.