http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010123465-A3

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filingDate 2010-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dea0193ac3396139990d8be9956d888
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publicationDate 2011-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2010123465-A3
titleOfInvention Method for the treatment of biomedical polymeric implants for the improvement of antithrombogenic properties thereof
abstract The subject of the invention is a method for the treatment of biomedical implants for the improvement of antithrombogenic properties thereof. The mentioned biomedical implants are cardiovascular implants, especially artificial blood vessels and stents made from a polyethyleneterephtalate (PET) polymer. The method is based on the treatment of a surface of cardiovascular implants by an adequate combination of a dose of neutral oxygen atom and positively charged molecular and atomic oxygen ions. After having been treated by a dose of said atoms and ions, the surface of cardiovascular implants becomes less prone to binding of thrombocytes. The method is characterised in that the exposure to a mixture of neutral oxygen atoms and positively charged molecular and atomic oxygen ions in pulses is such that in an individual pulse a dose of neutral oxygen atoms is reached between 10 20 m -2 and 10 26 m -2 , and the dose of charged molecular and atomic oxygen ions between 10 16 m -2 and 10 23 m -2 , the interval between individual pulses is between 10 s and 300 s, and that the flow of neutral oxygen atoms and positively charged molecular and atomic oxygen ions onto the surface of an implant is approximately even.
priorityDate 2009-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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