| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_376837b4e71590b96d29c40a6bd55073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b709597c2108e5f96668adcc84bba699
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1bf612b3df8713bf5a489cbf9255c98 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-46 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-3621
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0671 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate |
2010-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16c7715ca59fd8fb32ddf86db331a834
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97d9681998c0d1c0e83bd365470a8c14 |
| publicationDate |
2010-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010123357-A1 |
| titleOfInvention |
Differentiated human liver cell cultures and their use in bioartificial liver systems |
| abstract |
The present invention concerns human hepatocyte cell line cultures and their use in bioartificial liver (BAL) systems. These systems are used to treat subjects suffering from liver failure to temporarily compensate for loss of hepatocellular function and generally comprise a bioreactor loaded with functional liver cells. Until now, it has been problematic to acquire cells with a broad spectrum metabolic functionality, resembling that of freshly isolated human hepatocytes, to the extent that they are in fact suitable for successful clinical BAL application The present inventors have managed to develop human hepatocyte cell line cultures that display broad-spectrum metabolic functionality such as to render them particularly suitable for effective clinical BAL application. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3192870-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10188682-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10036052-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9969979-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015071264-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10179896-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014159622-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2871233-A1 |
| priorityDate |
2009-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |