| abstract |
An efficient and economical process for synthesizing kilogram quantities of an indole cyclopropyl amide derivative of Formula (I), or a pharmaceutically acceptable salt thereof, is disclosed. The process comprises the coupling of indolecarboxylic acid derivative 4, or its diethylamine salt, with cyclopropylamine 6 or its methanesulfonic acid salt. Compound (I) is an EP4 antagonist useful for treating prostaglandin E mediated diseases such as acute and chronic pain, osteoarthritis and rheumatoid arthritis. |