| abstract |
Beta-mimetic compositions and methods of making and using such compositions in preparing bioactive peptides, such as antimicrobial peptides, are disclosed. In particular, spirocyclic proline hybrids are provided that may be used to alter the cis/trans isomerization of proline in a peptide, and which may replace a residue, for example, the i + 2 residue, of a beta-turn in a peptide of known sequence, thereby retaining or modifying the structure of the peptide. |