| abstract |
The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T 1 , and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T 2 , wherein T 2 is greater than T 1 , and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T 2 , such that the active agent and matrix material are soluble in the organic solvent at T 2 . |