http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010105160-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2057c1f2902e8d11190f1137b3c28232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5513c4f3ebe2b6ae13b8b87eb430c7ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcce63b212704284382017151a108fc4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-2292 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-32 |
| filingDate | 2010-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37a075271e6df80675029c2a7c6564fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55b82cb3984f8c74c3538f537d028b17 |
| publicationDate | 2010-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2010105160-A2 |
| titleOfInvention | Method of treating hematological malignancies and hematological neoplasms |
| abstract | The invention relates to a method of treating hematological malignancies or hematological neoplasms in a subject, which comprises administering to a subject an effective amount of a peptide agent having actin-sequestering, actin-binding or actin-modulating peptide having a peptide motif as described herein, including the preferred motifs LKKTET (SEQ ID NO:10), KLKKTET (SEQ ID NO:25), LKKTETQ (SEQ ID NO:26) and LKKTNT (SEQ ID NO:11). Preferred peptides include TB4, a TB4 isoform, a TB4 N-terminal fragment, a TB4 C-terminal fragment, TB4 ala , TB9, TB10, TB11, TB12, TB13, TB14, TB15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, adsevertin, propomyosin, fincilin, depactin, DNaseI, vilin, fragmin, severin, capping protein, β-actinin, acumentin, TB4 sulfoxide, lymphoid TB4 or a functional variant thereof, and others, and any combination thereof. The method optionally further comprises administering a second agent, which can be a stimulating agent that stimulates production of the peptide agent and/or at least one antineoplastic agent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10161006-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015137738-A1 |
| priorityDate | 2009-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 214.