| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7db7cda3f41586711d08f8ff6efa9f94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b30195774f49bd00c208b6130d5634b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07957542e618b3b8f2b4ff4a007840b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a9e6421e9257148abad101e1ce6c162
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e96aafd071aa933826e7f6e3d6178f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec47e1da6c917aa6872b34751824bb59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_67dd1f39f37bac4617e37d6d5c60aa8b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23d17124ca79df20314c3a546616c4e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3076a052242d479312710cc0f8e9103d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef4b6560bf20f5bcbe701f466c792ef9 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-10 |
| filingDate |
2010-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e02ac6ec2df10e775e04fd784e87efe0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5193e9f46f5da0fb4a72637885ffa9d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b7a13fa639ee582e90b0bf6a50c1dae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0c53d2d52c7f3ae20f62a881e3dc191
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10dc117e359db7100c2ee169ea724026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bae307133a0be0b9bebed026afb29f1c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dce7adf394205e33132b5597a10d9f81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20641f1e579979d52b374148fb9706df |
| publicationDate |
2010-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010104193-A2 |
| titleOfInvention |
Intermediate compound for synthesizing pharmaceutical agent and production method thereof |
| abstract |
A production method of an optically active 2-{4-(5-substituted-oxadiazolyl) phenyl}morpholine which is useful as an intermediate for synthesizing a pharmaceutical agent is provided and the method comprises the following steps 1) to 4): 1) reacting a bromophenylmorpholine with a hexacyanoferrate(II) or a hydrate thereof at a temperature of from 110°C to 140°C in a reaction mixture comprising a Na 2 CO 3 , an organophosphorus compound, and a palladium catalyst in a polar aprotic solvent alone or combination of a polar aprotic solvent and other polar aprotic solvent or hydrocarbon solvent to give a cyanophenylmorpholine; 2) reacting the cyanophenylmorpholine with hydroxylamine or hydroxylamine hydrochloride at a temperature of from 10°C to 40°C in an aprotic polar solvent to give a hydroxylamine derivative; 3) reacting the hydroxylamine derivative with an acylation reagent selected from the group consisting of aliphatic acyl halides, aromatic acyl halides, aliphatic acyl anhydrides and aromatic acyl anhydrides; and 4) keeping the mixture obtained after step 3) at a temperature of from 60°C to 140°C to give a 2-{4-(5-substituted-oxadiazolyl) phenyl}morpholine. |
| priorityDate |
2009-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |