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filingDate 2010-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2010-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2010101870-A1
titleOfInvention Compositions and methods for generating interleukin-35-induced regulatory t cells
abstract Compositions and methods are provided for generating T cells having a regulatory phenotype from conventional T (T conv ) cells. Such compositions and methods include culturing isolated, naϊve T conv cells with an effective amount of interleukin-35 (IL-35) until the cells have the regulatory phenotype. Also provided are methods to treat subject having or susceptible to having various disorders including, for example, immune system disorders with the T cells having the regulatory phenotype.
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