| abstract |
Disclosed are methods and compositions for diagnosis, monitoring, treatment and management of cancer. More particularly, the present invention discloses the use of PITX2 as a diagnostic or prognostic marker of cancer including skeletal metastasis-associated, hormone-related cancers such as prostate cancer and breast cancer. The invention has practical use in diagnosing the presence, stage, degree or risk of development of cancer, in prognosing cancer, in monitoring clinically affected subjects, and in enabling better treatment and management decisions to be made in clinically and sub-clinically affected subjects. |