abstract |
The invention provides a composition comprising a nucleic acid sequence encoding a polypeptide which comprises a HIV-1 Gag amino acid sequence, except that amino acids 358-411 or amino acids 355-408 of the HIV-1 Gag amino acid sequence have been replaced with amino acids 359-412 of a SIV Gag polypeptide. The invention also provides a nucleic acid sequence encoding the above-described polypeptide. Also provided is a method of inducing an immune response against HIV-1 in a mammal comprising administering two or more nucleic acid sequences encoding HIV and SIV amino acid sequences. |