| abstract |
The invention is directed to modified polymers with increased drug-loading including compounds of formula (I): wherein Z is a poly(lactic-co-glycolic acid) (PLGA) polymer having molecular weight from 1-15 kDa and where the ratio of lactide to glycolide in the PLGA polymer is from 1:10 to 10:1; formula (II) R 1 are independently H, R 2 , OH, O-alkyl, -O-R 2 , NH-R 2 , -linker-R 2 , or - and R 2 are independently one or more therapeutic agents. The invention is also directed to nanoparticle drug delivery systems including a PLGA- b -PEG block copolymer; and a stabilizer and to drug delivery systems including PLGA- b -PEG block copolymer polyvinyl alcohol (PVA) nanoparticle; and the modified polymer substantially as described herein. |