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publicationDate 2010-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2010091041-A1
titleOfInvention Cell based assays for the triglyceride synthesis pathway
abstract A method for identifying a compound which modulates the activity of acyl-coA: diacylglycerol acyltransferase comprises the steps of contacting a stable isotope labeled fatty acid with cells in either presence or absence of the compound, extracting the cells with isopropyl alcohol, and determining the level of a stable isotope labeled triglyceride in the presence or absence of the compound; wherein a change in the level of the stable isotope labeled triglyceride indicates that the compound modulates the DGAT activity.
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