http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010087564-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_86bae6e61cd0cfeb79b021033eb90794 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dea48e8c4f3a3e6252a9f0fcd8676ade http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1584c21cf27f9e557aec39240422a393 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8aa2ac9320cf6b6231bd02a965cae586 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f188316ac5087899315ce4923ec5dcd5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-38 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70567 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0619 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate | 2009-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_caa0d32d77cac50a9302b4b852d6d389 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed4abc839625df50ca1d18e7e52d1e4b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42f382d1d8b9fb86e9fcde42f3249e3a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e8d6a200159b74ffdd42df51e5d047b |
| publicationDate | 2010-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2010087564-A2 |
| titleOfInvention | Method for inducing improved dopaminergic neurons by mutant nurr1 gene expression |
| abstract | The present invention provides a method for inducing dopaminergic neurons. The method comprises in vitro gene transfection to enable expression of a mutant Nurr1 gene in neural precursor cells, in which Akt-phosphorylation is significantly reduced by mutation of the conserved Akt-phosphorylation site of a Nurr1 protein. Further, the present invention provides transfected neural precursor cells enabling expression of the mutant Nurr1 gene in which Akt-phosphorylation is significantly reduced by mutation of the conserved Akt-phosphorylation site of the Nurr1 protein. In addition, the present invention provides a dopaminergic neural cell population induced from the neural precursor cells by expressing the mutant Nurr1 gene in the neural precursor cells. According to the present invention, the induction of the mutant protein expression in the neural precursor cells can generate dopaminergic neurons which are able to maintain Nurr1 protein concentration stably and natural Nurr1 function. The dopaminergic neurons produced by the mutant Nurr1 gene are resistant to toxic stimulation and ensure improved in vitro and in vivo viability after transplanting into a rat brain. |
| priorityDate | 2009-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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