| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3671e7ff1024b41f32749e5cc58b9828
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24fc63797829e1b454897b453df0daa5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b21d364454cbe536d03edbd984b22a6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2010-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6cf1848c5025e994e698db1193daa53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53f6bc514b777808a7c89a14e475d4aa |
| publicationDate |
2010-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010086597-A1 |
| titleOfInvention |
Delivery of nucleic acids using cell-penetrating peptides |
| abstract |
The present invention is based on the innovative concept of conjugating a cell- penetrating peptide (CPP), including a protein transduction domain, to a nucleic acid molecule to provide a nucleic acid-protein conjugate exhibiting enhanced cellular uptake. Accordingly, the invention provides a method of producing a cell permeable nucleic acid molecule conjugate nucleic acid including a nucleic acid conjugated with a homeodomain of an antennapedia homeotic transcription factor protein (Antp), or functional fragment thereof. The invention further provides compositions and methods treating a subject using the conjugates produced by the method described herein. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105555317-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110511273-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110511273-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9722307-B2 |
| priorityDate |
2009-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |