http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010082050-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_552fa133d6323c85af7a40a6c2b64f31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_66c1b22707b0276e3078713a6ddcba91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e7aa16d9dd577f0d7a1125bcbc5a13f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40ee08fc4d75f054907df8382f44831c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c984b33e02c79a537b4fca85f372d4b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ed915e47be4d525d89d753fc897c923 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4bf19d643f04772b34990010e165027 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5517 |
| filingDate | 2010-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cca5ab34a823fee6e19628ee6162207d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe3c0b01162cc7396ec6cafc54a58ad9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26619c1471c01adae70a46519e508e02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c3a143b69559be8485db61aaf200667 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9849fc742ea209501e9ba6ed6982a65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0626ce88353022a1275b85c6a94d1756 |
| publicationDate | 2010-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2010082050-A1 |
| titleOfInvention | Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections |
| abstract | The present invention provides a compound of formula (I), wherein R 1 is selected from hydrogen, hydroxyl, fluoro or a C 1-4 alkoxy group or R 1 is linked to R 3 to form a 4, 5 or 6-membered aliphatic ring optionally containing one N or O atom; R 2 is selected from cyclopentyl or cyclohexyl optionally substituted by a fluoro; R 3 is hydrogen or is linked to R 1 as hereinbeforedefined; R 4 is hydrogen, a C 1-4 alkyl group optionally substituted by a group NR 8 R 9 in which R 8 and R 9 are each hydrogen or a C 1-4 alkyl group or R 4 is linked to R 6 to form a (CH 2 ) m NR 10 SO 2 N group wherein m is an integer selected from 2 or 3 and R 10 is a C 1-4 alkyl group; R 5 is hydrogen or a C 1-4 alkyl group; R 6 is hydroxyl or is linked to R 4 as hereinbefore defined; R 7 is hydrogen or an aliphatic ring of 4-7 ring atoms containing one or two heteroatoms selected from O, N or S or a group S(O), S(O) 2 ,NH or NC 1-4 alkyl and optionally substituted by fluoro or R 7 is a 5- 10-membered heteroaromatic ring system containing 1 to 4 heteroatoms independently selected from N, O and S, which ring is optionally substituted by one or two halo atoms or C 1-4 alkyl or C 1-4 alkoxy groups; Y is a single bond or a CH 2 group; when R 4 is linked to R 6 and m is 3 then Y is a single bond; when R 4 is linked to R 6 and m is 2 then Y is a CH 2 group; n is an integer from zero to four, with the proviso that when R 1 is hydrogen, n is not zero; or a pharmaceutically acceptable salt thereof, pharmaceutical formulations containing it and its use in medicine, particularly for the treatment of HCV infections. Hepatitis C (HCV) is a cause of viral infections. Methods of preparing compounds of the formula (I) arc also disclosed. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7977331-B1 |
| priorityDate | 2009-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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