Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_934b1808ff65c1c06e71e38014849799 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82ae8798cdec6cc8f8ad3eb62813831e |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-342 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-344 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-52 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1131 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 |
filingDate |
2009-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_143d7cfe2e0c0e64ccd191a3c4091733 |
publicationDate |
2010-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2010080129-A2 |
titleOfInvention |
Extended dicer substrate agents and methods for the specific inhibition of gene expression |
abstract |
The invention provides compositions and methods for reducing expression of a target gene in a cell, involving contacting a cell with an isolated double stranded nucleic acid (dsNA) in an amount effective to reduce expression of a target gene in a cell. The dsNAs of the invention possess a pattern of deoxyribonucleotides (in most embodiments, the pattern comprises at least one deoxyribonucleotide-deoxyribonucleotide base pair) designed to direct the site of Dicer enzyme cleavage within the dsNA molecule. Deoxyribonucleotides of the dsNA molecules of the invention are located within a region of the dsNA that can be excised via Dicer cleavage to generate an active siRNA agent that no longer contains the deoxyribonucleotide pattern {e.g., deoxyribonucleotide-deoxyribonucleotide base pairs). Such DNA-extended Dicer-substrate siRNAs (DsiRNAs) were demonstrated to be more effective RNA inhibitory agents than corresponding double stranded RNA-extended DsiRNAs. DsiRNA agents were also found to tolerate guide strand mismatches. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10487330-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019074071-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013059496-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3892727-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10435692-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4035659-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022221457-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10465195-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3444350-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022256351-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3597644-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11060093-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014153163-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3581654-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10689647-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4012031-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3960726-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11667918-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11298371-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11725207-B2 |
priorityDate |
2008-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |