| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa5c640f2c0ebefbfcf5e7bfa0175eb3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_896c9bf4940aa4083a5c83b9b3a21a25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d622378c3e4e8b893f2273bdff41e68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_806f0a3a49d26f0b2efb79a3ea184ce9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_439812bf0e06c0558be8fecb3b810e0c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aad427eb4d6796c5634021a62559e9bc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_207679c4a0849b9c83e5b8362ff57e77 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-922
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-20 |
| filingDate |
2009-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_760ab0d8d227a2caeaf83f912bae8796
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_412969a7144f0b0742ce0698c458ba13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02a369c0dbbabab2eb57791ab6409b32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_442526970ec09f9c8e91f077a2925721
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b41ad46aac325212f3404eceecba5908 |
| publicationDate |
2010-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010069600-A2 |
| titleOfInvention |
Polypeptide fragments comprising endonuclease activity and their use |
| abstract |
The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting. This invention also relates to compounds and pharmaceutical compositions comprising the identified compounds for the treatment of disease conditions due to viral infections caused by viruses of the Orthomyxoviridae family. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8859290-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018007615-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2402365-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013090300-A1 |
| priorityDate |
2008-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |