| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4465d64ba7d7a76999eceb0bba797f58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4781a4ea06b1dba2843cd3f86e22f95b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4a9dfb473149996e4b79e48c8dc6af45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_810be5506ecf4ae16663685767125ed1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3653d84bbc53fe7f976cc3942ae47b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c4322cb4de342be2dbedcbe0c278f6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-726
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-727
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-728
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-726
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-727
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2009-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79d1272f89cdf16e6223a5532a7eca5e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8b3d67efbe379d0e97d9d9cd9e148f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b1fee829187ce842c35f7db8a01372b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_074da44281a33c7cfe201e99163da9ac |
| publicationDate |
2010-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010068308-A1 |
| titleOfInvention |
Inhibition of inter-alpha trypsin inhibitor for the treatment of airway disease |
| abstract |
It is disclosed herein that blockade of inter-alpha-trypsin inhibitor (IaI) prevents the development of airway hyperresponsiveness in animal models of asthma and chronic obstructive pulmonary disease. Provided herein are methods of treating an airway disease or disorder in a subject by administering to the subject a therapeutically effective amount of an inhibitor of IaI. Also provided is a method of preventing or reducing airway hyperresponsiveness in a subject by administering to the subject a therapeutically effective amount of an inhibitor of IaI. The IaI inhibitor can be any compound that inhibits the expression or activity of IaI or a gene encoding an IaI polypeptide. In some embodiments, the IaI inhibitor is administered locally to the airway of the subject in need of treatment. For example, the inhibitor can be administered by aerosol delivery, such as by using an inhaler or nebulizer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9572872-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10258675-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE47972-E
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10076559-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8807131-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013172923-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2827877-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015238578-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9758570-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9717752-B2 |
| priorityDate |
2008-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |