| abstract |
The present invention relates to a pharmaceutical composition and the method of manufacture thereof, wherein said composition serves to treat internal tissue and organ burns caused by corrosive substances, comprising pharmaceutically acceptable melatonin, polyethylene glycol, vehicles and excipients in the preparations. Ingestion of caustic substances is one of the most life-endangering accidents in the paediatric age group, requiring immediate handling and subsequent treatment of one of the most significant complications, for example alterations in the structure of the oesophagus. Melatonin reduces the oxidative response and the quantity of hydroxyproline in the late phase of oesophageal burning induced by sodium hydroxide. |