| abstract |
Disclosed is a novel compound having an action mechanism different from that of statin drugs, which has an excellent ACAT-2 inhibitory activity and is useful for treatment or prevention of obesity, adiposis, hyperlipemia, hypercholesterolemia, dyslipidemia, arteriosclerosis and the like. The compound is a beauveriolide derivative represented by general formula (I) or (II), wherein R1 represents a methyl group or H, R2 represents, for example, a butyl group, X represents an alanine residue, and Y and Z represents an amino acid residue (for example, Y is a phenylalanine residue and Z is a phenylalanine, isoleucine or leucine residue), or a salt, solvate or hydrate of the derivative. The compound can be used as a pharmaceutical composition together with a pharmaceutically acceptable carrier thereof. |