| abstract |
The invention deals with preparation of the substance prasugrel, using 3- cyclopropyl-1 -(2-fluorophenyl)-3-oxopropyl methanesulfonate for alkylation of 2-oxo- thienotetrahydropyridine, which may be in the form of a salt, e.g. with hydrochloric acid or p-toluenesulfonic acid. The resulting compound of formula II is acylated, preferably with acetanhydride, preferably directly in the reaction mixture without isolation, and the produced prasugrel of formula I can then be crystallized directly from the reaction mixture. |