http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010058430-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b0091747f8feedf6f736eb5d16b1c6c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94fe51a1c2cb64572a462ac6fede837f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7a3886f1cdaa7211491a8f2de9831c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aed73ede30d4705652e0718ea99e30d7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2009-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5fc957915a85bdc2e0ccd0d4fa70a05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24ebe2cef9f131bbb658053e81d2662e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2067388b0a6f8418d7033263159b0a9e |
| publicationDate | 2010-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2010058430-A1 |
| titleOfInvention | Process for the preparation of tetrazine derivatives |
| abstract | The present invention provides a process for the preparation of a tetrazine derivative of formula (I), or a pharmaceutically acceptable salt thereof wherein R 1 represents a hydrogen atom, a straight or branched C 1 -C 6 alkyl group, C 2 -C 6 alkenyl group or C 2 -C 6 alkynyl group, which C 1 -C 6 alkyl group, C 2 -C 6 alkenyl group and C 2 -C 6 alkynyl group is unsubstituted or substituted with 1, 2 or 3 substituents selected from halogen atoms, straight or branched C 1 -C 4 alkoxy groups, C 1 -C 4 alkylthio groups, C 1 -C 4 alkylsulphinyl groups, C 1 -C 4 alkylsulphonyl groups and phenyl groups, which phenyl groups are unsubstituted or substituted with one or more substituents selected from C 1 -C 4 alkyl groups, C 1 -C 4 alkoxy groups and nitro groups; or R 1 represents a C 3 -C 8 cycloalkyl group; and R 2 represents a group of formula -(C=O)NR 3 R 4 , wherein R 3 and R 4 are independently selected from hydrogen atoms, C 1 -C 4 alkyl groups, C 2 -C 4 alkenyl groups and C 3 -C 8 cycloalkyl groups, which process comprises: i) providing a compound of formula (III), wherein R 1 is as defined; R 1 -N=C=O ii) absorbing the compound of formula (III) into a solvent to obtain a solution of the compound of formula (III); iii) adding to the thus obtained solution a compound of formula (II), to obtain a compound of formula (I), as defined above, wherein R 2 is as defined above; iv) decomposing any excess compound of formula (III) remaining by addition of water; and v) optionally salifying the thus obtained compound with a pharmaceutically acceptable acid, or base. |
| priorityDate | 2008-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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