| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca3f461cf260288781d3632c0b4bfa4f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e3830f35387a1c32061dea3ee310851 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-45 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N37-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 |
| filingDate |
2009-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_862b98149c4a0a3e92b0df4541312086 |
| publicationDate |
2010-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010056735-A1 |
| titleOfInvention |
Compositions and methods for inhibiting an oncogenic protein to enhance immunogenicity |
| abstract |
The present invention includes compositions and methods for inhibiting an oncogenic protein or its down-stream effector protein to suppress expression of a cell-surface protein involved in inhibiting immune response against malignant cells thereby enhancing immunogenicity of a cell. The invention includes inhibitors of expression of CD274 and/or its functional cell-membrane bound immunosuppressive analog. The invention includes inhibitors of function or expression of oncogenic ALK tyrosine kinase and/or other oncogenic proteins responsible for induction of expression of CD274 or its functional immunosuppressive equivalent. The invention includes inhibitors of function or expression of STAT3 and/or other cell signal transmitters and/or transcription factors activated by ALK or its functional analog involved in induction of expression of CD274 or its functional analog. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2019271922-C1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2019271922-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PH-12018500365-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11299544-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3633377-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013019906-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10946093-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9920123-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10646567-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-026924-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103842030-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103842030-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110234764-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9724413-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110234764-B |
| priorityDate |
2008-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |