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publicationDate 2010-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2010055866-A1
titleOfInvention Polyalkylene glycol derivative and method for producing same
abstract A method for producing a polyalkylene glycol derivative which has a molecular weight and purity high enough to be used in pharmaceutical applications. Specifically disclosed is a method for producing a polyalkylene glycol derivative represented by formula (X) R-(OA) n OH by steps (A), (B), (C),(D) and (E). Step (A): An alkali catalyst is added to a compound represented by formula (Y) R-OH in an amount of 5-50% by mole. Step (B): A polyalkylene glycol derivative is obtained by reacting an alkylene oxide having 2-4 carbon atoms at a temperature of 50-130˚C until the average mole number of added oxyalkylene groups (OA) reaches the range of 5-500. Step (C): The derivative of step (B) is diluted by adding 10-5,000% by mass of a hydrocarbon solvent, and the remaining water content is removed by azeotropy. Step (D): The derivative of step (B) is reacted with an alkylene oxide having 2-4 carbon atoms at a temperature of 50-130˚C until the average mole number of added oxyalkylene groups (OA) (n) reaches the range of 600-2,000.
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