| abstract |
Disclosed is an O-alkylserine which is useful as a pharmaceutical intermediate. Also disclosed is a process for producing an N-benzyl-O-alkylserine, which is a compound useful for the production of the O-alkylserine, on an industrial scale from a readily available starting material by using an inexpensive reagent in a simple and highly efficient manner. A compound represented by formula (3) is hydrolyzed to produce a reaction solution. The N-benzyl-O-alkylserine is isolated in the form of crystals from the reaction solution directly. Particularly preferably, a 1-benzylaziridine derivative, which is a readily available compound, is subjected to the ring opening reaction with an alcohol and a Bronsted acid to produce a compound represented by formula (3). The N-benzyl-O-alkylserine is debenzylated to produce the O-alkylserine. |