| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b6ce39868f73a4bbb6584c7b8daef61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb593c83cf8397900d9fdae06b345b38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_310ea15a7cdd459a8e20d80cb0f21f88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df997abbb93222ecf78a9bf317bf4ac3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_646abaede308a69e6596a0063d69d2c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad07969aee3ec116a061f28016e71d5d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L5-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-126
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-003 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00 |
| filingDate |
2009-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c18592be9e2f77c448cadbd1848d195d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fa451f24361b9748cd8592ddf51f552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4e5d18f401586cbe76a844778d5ffb5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e858294c10ac75eefe3fc79deb0bde25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50636b1e8217e155e813f970152c406f |
| publicationDate |
2010-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010051783-A1 |
| titleOfInvention |
Method of preparation of dtpa crosslinked hyaluronic acid derivatives and modification of said derivatives |
| abstract |
The invention relates to the modification of hyaluronic acid by means of a protonized DTPA bis anhydride in a non-basic polar aprotic solvent in absence of any external base to form crosslinked products. The reaction runs via the formation of a complex and the acylating agent is the hyaluronan co-cation itself, i.e. protonized DTPA bis anhydride. The final crosslinked derivative (linker) comprises three carboxylic groups and three tertiary amines which are capable of complexing various metals effectively. The final DTPA crosslinked hyaluronic acid may also be hydrophobized by means of mono, bis or tris functional alkylating agents. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10618984-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10759878-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109890847-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9492586-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10023658-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9403918-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10617711-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9999678-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10414832-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9522966-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013159757-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10689464-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9434791-B2 |
| priorityDate |
2008-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |