| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_510040b8e459bfc5488aa99e2b025be1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b2c49d16e6ecc729099d6f3589e7d79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d4692bccd58e7649ba19bc6b7cb2f846
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6f2dfd800f5740a25a62ba57f6c4271 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70571
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 |
| filingDate |
2009-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa3080f88fb31e81d6745eb0f2c0eb36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcb02985aaf7d65b6150621a10f809e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52d83e26d41408a6d68670a7eccb6200 |
| publicationDate |
2010-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010042799-A2 |
| titleOfInvention |
Novel chimeric ligand-gated ion channels and methods of use thereof |
| abstract |
The present invention provides novel chimeric receptors that have unique pharmacology. In particular, the chimeric receptors comprise a mutated ligand binding domain of the α7 nicotinic acetylcholine receptor fused to a transmembrane or channel domain from a ligand-gated ion channel protein. The mutations in the ligand binding domain confer selective binding of compounds. Methods of using the novel chimeric receptors of the invention as well as compounds that preferentially bind and activate the chimeric receptors are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10981962-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8987453-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11407812-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11124554-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11713470-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11046658-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014503600-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11084853-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3349760-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10538571-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014503599-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9464078-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10961296-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018175443-A1 |
| priorityDate |
2008-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |