Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_886efd3fac618c7f32e16427e85908e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef2d3267a2ea00a896b26d95051ce29f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22d5e4058e5f055688d3a4dd3290cc8d |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-999 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0695 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
filingDate |
2009-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0877a98ec873ede274cad87b2d83ba00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_377f50312b26c624d3c3fd022f35c24b |
publicationDate |
2010-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2010037134-A2 |
titleOfInvention |
Multi-stage stem cell carcinogenesis |
abstract |
The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103702555-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104080907-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105264089-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2749642-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012164413-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9874574-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9198986-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014200256-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102180733-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102130501-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105264089-B |
priorityDate |
2008-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |