http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010036408-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cea139ad438b9ce7d33159d45b154c6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6bbee82108ad927eddffb12f4e186bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96cbb2a26d2c554c07e00731716f2215 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-01017 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-24075 |
| filingDate | 2009-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d212a26046526dce07fbf13c99f8ca3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9452dee1cb924a03d572a41d3ea718ab |
| publicationDate | 2010-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2010036408-A2 |
| titleOfInvention | Lysk endolysin is synergistic with lysostaphin against mrsa |
| abstract | Multi-drug resistant superbugs are a persistent problem in modern health care. LysK is a staphylococcal bacteriophage endolysin from the phage K. It is a peptidoglycan hydrolase enzyme that can lyse many staphylococcal strains and thus is a potent antimicrobial against S. aureus , including MRSA. Lysostaphin is a bacteriocin secreted by S. simulans to kill S. aureus , and has been shown to also be a potent antimicrobial for many antibiotic resistant strains of S. aureus . This study describes optimal reaction conditions for the recombinant His-tagged LysK protein, compares its MIC and antimicrobial activity to lysostaphin and demonstrates synergy when the two are used in combination against the MRSA USA300. |
| priorityDate | 2008-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 197.