| abstract |
The present invention relates to a monoclonal antibody (mab) for human mutant transthyretin (TTR), a kit for the detection of FAP comprising the referred mab, methods for its production and its uses such as in screening for familial amyloidotic polyneuropathy (FAP) and pathologies presenting modified forms of TTR, and in research and treatment of associated diseases thereof. This monoclonal antibody presents as main characteristic the recognition of amyloidogenic plasma mutant TTR and modified TTR. These properties are assigned to unique sequences of the mab that reacts with a cryptic epitope in TTR that is exposed by mutant and/or modified TTR implying a high specificity for modified forms of mutated and non-mutated plasma TTR. The mab of the invention finds use in epidemiological studies of TTR amyloidogenic mutations in the population and in biomarker studies associated with pathologies presenting modified TTR. |