| abstract |
The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamidc, or alkyl-urea or alkyl- sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: - R represents hydrogen or C 1-4 alkyI, - A represents CO(CH 2 ) n or CONH(CH 2 ) n where n = 2, 3, 4, or 5, - R1 and R2 are as described herein. |