| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_700ff9a01db2075489cb7ed87392dc28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41a639aa11b9b2f8063a3e6b8b22b557
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d14846f96e774b3cbd1cf41d947ee5e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b41e6bacd73e79e024526cb3fba2fbd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4a3b81bba468d2e9b84d4447662044c5 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4846
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4853
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-366
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-727
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-737 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-727
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-737
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-04 |
| filingDate |
2009-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7513557794bfd85e4683b18662f33145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_272b95320b5d50de767953ea9990cd6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83355de94f0a24c462d0d9fef2b02ae4 |
| publicationDate |
2010-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010020423-A2 |
| titleOfInvention |
Methods for treating bleeding disorders |
| abstract |
A method of factor Xl-dependent blood coagulation enhancement in a subject in need of enhanced blood coagulation comprising administering a therapeutically effective amount of a composition comprising a non-anticoagulant sulfated polysaccharide (NASP) to the subject. A method of factor Xl-dependent blood coagulation enhancement in a subject in need of enhanced blood coagulation comprising: (i) selecting a subject that is not deficient for factor Xl; and (ii) administering a therapeutically effective amount of a composition comprising a non-anticoagulant sulfated polysaccharide (NASP) to the subject, wherein the NASP enhances blood coagulation in a factor Xl-dependent manner. A method of identifying a non-anticoagulant sulfated polysaccharide (NASP) which is capable of enhancing blood coagulation in dependence on FXI, the method comprising: a) combining a blood or plasma sample comprising activation competent FXI with a composition comprising a sulfated polysaccharide and measuring the clotting or thrombin generation parameters of the blood or plasma sample; b) combining a corresponding blood or plasma sample deficient in activation competent FXI with a composition comprising the sulfated polysaccharide and measuring the clotting or thrombin generation parameters of the blood or plasma sample; and c) comparing the clotting or thrombin generation parameters of the blood or plasma samples as determined in steps (a) and (b) with each other, wherein a decrease in the clotting time of the blood sample or an increase in peak thrombin or decrease in peak time of the plasma sample comprising activation competent FXI compared to the clotting time of the blood sample or peak thrombin or peak time of the plasma sample deficient in activation competent FXI is indicative of a NASP which is capable of enhancing blood coagulation in dependence on FXI. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3594686-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012066260-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013035288-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2967781-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9417251-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2662083-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2012284048-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11220554-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9891238-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013167303-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014520889-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9707269-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846620-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10232015-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104302296-A |
| priorityDate |
2008-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |