http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010018950-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e94e42597ee709fb8d1546abab3422e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56820bbb13a42311271e147869a36d30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e625f43a6153554dae331f027dd10afd http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ccf41f8506f32f80c2efb5567b546ce0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-10 |
| filingDate | 2009-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c7ee47b5dd04a3ea345b4b19a5ebe34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce48a37238935273f673c8d06684b9fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acb6a2efd0754ed4efe74652dbbe1d09 |
| publicationDate | 2010-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2010018950-A2 |
| titleOfInvention | Protein scaffold library based on kringle domain structure and uses thereof |
| abstract | There are provided a Kringle domain structure, comprising: inducing artificial mutations at amino acid residues except for conserved amino acid residues that are important to maintain the structural scaffold of a Kringle domain; and protein scaffold variants, based on the Kringle domain structure, which modulate the biological activities of a variety of target molecules derived from the protein scaffold library by specifically binding to the target molecules. Also, there is provided a method for constructing homo-/hetero-oligomers which allow multi-specificity binding to multiple targets by the tandem assembly monomeric Kringle domain variants using a linker. Additionally, there is provided a method for preparing multispecific monomers and multivalent monomers by grafting target-binding loops of a Kringle domain variant into non-binding loops of another Kringle domain variant with the same or different target binding specificity. Furthermore, a protein scaffold variant based on the Kringle domain structure that specifically binds to target molecules, DNA encoding the protein scaffold variant, or a method and composition for prevention, detection, diagnosis, treatment or relieving of diseases or disorders, particularly cancers and other immune-related diseases, comprising: administering an effective amount of the related molecule to animals, preferably human. |
| priorityDate | 2008-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.