| abstract |
The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), capable of decreasing or silencing gene expression of PLKl gene. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a PLKl mRNA. Also provided are methods of decreasing expression of a PLKl gene in a cell or in a subject to treat a PLK family member-related disease. |