| abstract |
Methods and compounds useful for inhibiting a phoshpolipase A 2 are provided, the methods comprising contacting the phoshpolipase A 2 with a compound having the structure A, or pharmaceutically acceptable salts thereof: wherein R 1 is H, F, NH 2 , or COOH; R 2 is, H, linear saturated or unsaturated alkyl, alkenyl, or alkynyl; each of R 3 and R 4 is independently H, linear saturated or unsaturated alkyl, alkenyl, alkynyl, phenyl, or substituted phenyl; R 5 is H, (C 1 -C 6 ) alkyl such as methyl or ethyl; X is aryl or substituted aryl, such as phenyl or a substituted phenyl; and Y is O or S. |